Scientific Evidence

The evidence behind Pentahibe

Whether you are evaluating a new cryopreservation strategy, comparing alternatives to traditional 10% DMSO formulations, or seeking application-specific data, this section provides access to the scientific evidence supporting Pentahibe.

From peer-reviewed research to practical application insights, explore how PentaHibe is helping researchers advance cell therapy, stem cell, immune cell, and organoid workflows while reducing reliance on DMSO.

Publications
Ref 1: Svalgaard JD et al. Cell Transplantation, 2018 Sept; Vol 27(9): 1407-1412
Pentaisomaltose, An Alternative To DMSO. Engraftment Of Cryopreserved Human CD34+ Cells In Immunodeficient NSG Mice
Ref 2: Svalgaard JD et al. Transplantation and Cellular Engineering, 2016 May; Vol 56(5): 1088-1095
Low Molecular Weight Carbohydrate Pentaisomaltose May Replace Dimethyl Sulfoxide As A Safer Cryoprotectant For Cryopreservation Of Peripheral Blood Stem Cells
Ref 4: Haastrup EK et al. Transplantation and Apheresis Science, 2021; Vol 60(4): 103138
DMSO (Me2SO) Concentrations Of 1-2% In Combination With Pentaisomaltose Are Effective For Cryopreservation Of T Cells
Ref 5: Svalgaard JD et al. Cryobiology, 2020; Vol 96(01): 207-213
Cryopreservation Of Adipose Derived Stromal/Stem Cells Using 1–2% Me2SO (DMSO) In Combination With Pentaisomaltose: An Effective And Less Toxic Alternative To Comparable Freezing Media
Ref 8: Hamann A et al. Application Note, 2025 August
Superior Cryopreservation of T Cells in Low-DMSO, Animal-Origin-Free Formulation Using Optibumin 25 and PentaHibe® Base
White Papers
Preserving Functional Performance of Human T Cells with PentaHibe® Complete
Optimizing Cryopreservation Performance in T-Cell Therapy Workflows
PentaHibe® — A safe cryoprotectant for advanced cell therapies
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